Please Critique my Experiment Design: Self-Experiment to Sleep Longer

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Summary: I’m trying to sleep longer, but am waking up too early in the morning. I’d like to test some interventions to sleep longer (including melatonin) and am looking for advice.

Over the past 5 weeks, I’ve been making an effort to get more sleep. I’ve been able to hit an average time asleep of ~7h and, qualitatively, I’ve been feeling a lot less tired and have been able to concentrate better in the afternoons.  

I’d like to see if sleeping even longer will result in further improvement. However, over the last week I’ve noticed that I’ve been waking up earlier and earlier (before my morning alarm). I stay in bed (eyes closed) until the alarm, but can’t go back to sleep.

Based on my data so far, there’s no clear correlation with time I fell asleep or total time asleep. Might be a correlation with heart rate variability, but I need more data to be sure.

I’d like to test some interventions to sleep longer. I already exercise in the evenings and for as long as I’m willing to do (~30 min. high intensity, 5-10 min. stretching), my last meal is 4h before going to bed, and my CGM does not show a consistent rise in blood sugar before waking up.

The only thought I had was to try melatonin. It’s typically used to control when you go to sleep, but it last long enough in the bloodstream that it might impact time asleep as well.

Plan:

  • Self-blinded study using melatonin placed inside placebo capsules
  • Concentrations: 0, 0.3, 3 mg (random assignment)
  • Duration: 4 weeks

Questions:

  • Anyone else have the same problem? What has worked for you to sleep later?
  • Any other suggestions for interventions to try?
  • Any comments or critiques on the melatonin experimental design?
    • Is random assignment by day sufficient or do I need to block by a longer time period, use washout days, etc.?


– QD


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I’m Back / Weekly Health Statistics

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I’m going to give blogging another go. To minimize the risk of getting overwhelmed/too busy, I’m going to start slow with a weekly post on what I’m tracking, observations, and active & planned experiments. I’ll supplement that with other ad-hoc posts.

Summary:

What I’m tracking

  • Sleep: 
    • Method: Apple watch + Autosleep app
    • Metrics: total time, heart rate variability, pulse (sleeping vs. waking)
  • Blood glucose:
    • Method: Dexcom G6 CGM
    • Metrics: fasting BG, Avg. BG, coefficient of variation, time 70-140 mg/dL, time <60 mg/dL
  • Body:
  • Other blood:
  • Urine:
    • Method: Vessel
    • Metrics: biotin, ketones, pH, vitamin C, magnesium, hydration, & cortisol

Observations

  • Sleep:
    • Sleep was way down this week. My family was on vacation Sunday through Wednesday, which typically results in me sleeping poorly.
  • Blood glucose:
    • TIR & CV% are much better this week. Introspection suggests this is due to a combination of eating smaller meals and the fact that I’m paying more attention now that I’ve resumed aggressive self-tracking.
  • Body:
    • Still seeing steady drop in weight and waistline. I’m very happy with my progress here. 
    • I had higher insulin sensitivity when I was at my target weight, so I need to keep a close eye on my time low as I continue to lose weight.
  • Blood:
    • My hemoglobin is on the high end of normal range. Nothing to be concerned about, but interesting. I’m curious if there are any dietary interventions that would significantly boost hemoglobin. Maybe in studies on athletic performance?
    • Total cholesterol is staying steady at ~160 mg/dL, which is fine. 
    • The Curo L5 has failed to read my HDL & triglycerides three weeks in a row, with no obvious reason why. The Cardiocheck PA was was able to read both and with sensible numbers (close to my lab test last week). It also gave the same total cholesterol and was easier to use. I will switch to the Cardiocheck going forward. 
    • HDL is a bit low & LDL a bit high. Nothing super concerning, but I will look into ways to improve.
    • Blood pressure continues to run slightly high. Not sure if I trust the absolute value of the home meter. Will need to check against the Dr’s at my next appointment
  • Urine:
    • Nothing interesting in this data. My values for biotin, pH, & Vitamin C are outside of the “normal” range, but I haven’t been able to find any literature indicating that this is even correlated with medical issues I would be concerned about.
    • In 4 tests, I’ve only gotten a reading on cortisol once. That measurements seems to be extremely unreliable.
    • All-in-all, I’m not getting much value out of the vessel tests. I will finish out the back I bought and then stop.

Active & Planned Experiments

  • Comprehensive bloodwork:
    • Goal: Establish baseline for a broad range of biomarkers and check overall health
    • Approach: WellnessFX Premium panel
    • Status: Got the results, need to analyze and write up.

Data:

Urine

Blood

Body

Sleep

Methods:

Measurements: 

Data Processing & Visualization. Data was visualized using Tableau.

Data: here


– QD


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